Fungi constitute a valuable source of pigments because they are capable of producing high yields of the substance in the cheap culture medium, making the bioprocess economically viable on the industrial scale. pheomelanin. However, it is necessary to expand the knowledge about the structure-property-function relationships for the development of melanin-based technology. 6 (December 2008): 525-31,https://doi.org/10.1016/j.mib.2008.09.013. Feb 19, 2023. Additionally, we discussed the ways to explore the metabolic potential of the pigment-producing fungi by manipulation of cultivation conditions to improve performance of the process, increasing yields, and reducing cost, for large-scale production. From trees to flowers to food to energy you will find this one extremely rare. This workis reproduced and distributedwith the permission of GreenMedInfo LLC. This pigment has been reported to act as fungal armor due to its ability to protect fungi from adverse conditions, neutralizing oxidants generated in response to stress. Search the history of over 797 billion It has been reported that melanin protects melanocytes and keratinocytes from the induction of DNA strand broken by hydrogen peroxide, indicating that this pigment also has an important antioxidant role in the skin [107]. It was demonstrated that the melanin produced by fungus Lachnum singerianum YM296 significantly inhibited the formation of lipid peroxidation products and slowed down the aging process, elevating the levels of superoxide dismutase, glutathione peroxidase, and catalase and decreasing the level of malondialdehyde in mice liver and brain homogenate and serum, suggesting that this pigment could be used as a new anti-aging drug [109]. 24. As the molecule that is crucial in determining skin color, melanin has fundamentally shaped the way we humans perceive ethnic and racial differences and tribal affiliation. This strategy may represent an added value to the industry and also helps in solving pollution problems, reducing or preventing their disposal in the environment [1, 66, 67]. As PhD students, we found it difficult to access the research we needed, so we decided to create a new Open Access publisher that levels the playing field for scientists across the world. @DESIRE | You #Enslave or are-Enslaved. These results suggest that melanin from A. nidulans has potential as an anti-inflammatory agent and may be used in the future for development of new drugs with therapeutic utility [32]. $33.33. 1 (August 2011): 69-73,https://doi.org/10.1016/j.bioelechem.2011.04.009. Motohiro Takeda et al., Biophoton Detection as a Novel Techniquefor Cancer Imaging,Cancer Science95, no. 68 pages, Paperback. In recent years, the electronics industry has been driven to develop materials and components that are cheaper and more environmentally friendly. WebMelanin: The Chemical Keys to Black Greatness (Vol. Buy on Amazon. Melanin is a biological molecule associated with pigmentation in humans and animals. This would explain the increased growth rate, even under low nutrient conditions, in certain kinds of gamma-irradiated fungi. These results can be explained by melanin or other natural pigments present in the cell wall of these fungi that can act as the radiation receptor and/or as an energy transporter for metabolism. Our studies demonstrated that melanin extracted from a highly melanized mutant (MEL1) of A. nidulans inhibited NO production in LPS-stimulated macrophages, with a maximum response of 82% inhibition, and also showed a dose-dependent inhibitory effect on TNF- production, reaching an inhibition of 51.86% at a melanin concentration of 100 g/mL. By making research easy to access, and puts the academic needs of the researchers before the business interests of publishers. Book details & editions. This will allow me to plunge deep into my bag of information acquired over the years as well as the knowledge gained from film school to create videos full time. However, melanin has been observed to have other functions such as neuroprotection and energy production. Genres History. This study suggested that A. auricular melanin inhibits quorum-sensing (QS)-regulated biofilm formation in all strains tested without interfering with their growth [122]. The development of these higher cognitive processes allowed for the materialization of sophisticated technologies, the agrarian revolution, hierarchical social structure, and advanced human civilizations. According to Dr Timothy Moore In humans, melanin is the primary determinant of skin and hair colour 6 (June 2008):890-99,https://doi.org/10.1016/j.jenvrad.2007.11.020. Watch on QUALIFIED IMMUNITY PACKAGES POLICE STOP/ LAW & GOV FLASHCARDS (PSFC) & (LGFC) 26. Police Stop Law Packages CRC - Know Your Rights Manual - Qualified Immunity Notices Constitutional Rights Cards & Police Bond Liens! The extracellular fungal melanin, which is found in culture fluids usually in the form of granules, can be formed from some culture components, which are autoxidized or are oxidized by phenoloxidases released from the fungus during autolysis [10, 11, 27]. The effect of melanin enhancing the survival of fungi under adverse conditions is mainly due to its function as an extracellular redox buffer, which can neutralize oxidants generated by the fungus in response to environmental stress [19]. Melanin in cell walls of Basidiomycotina is derived from phenolic precursors, as glutaminyl-3,4-dihydroxybenzene (GDHB) or catechol. It has been reported that various types of peptone, used as a nitrogen source, are able to promote an increase in the production of pigments in many species of fungi [55, 59, 62, 63]. WebMelanin, the What, the Why and the How: An Introductory Review for Materials Scientists Interested in Flexible and Versatile Polymers A. Bernardus Mostert Citation:Mostert, A.B. These studies have shown that fungi can produce different types of melanins by oxidative polymerization of phenolic or indolic compounds [11, 27]. I) by Carol Barnes Melanin: The Organizing Molecule Berkley CA: Institute for the Study of Consciousnesses (Thesis) Message To The Blackman in America by Elijah Muhammad Metu Neter Vol. (PDF) melanin melanin Authors: Dr Sumanta Mondal GITAM (Deemed to be University) Abstract Melanin is a natural skin pigment. neuromelanin. (PDF) melanin melanin Authors: Dr Sumanta Mondal GITAM (Deemed to be University) Abstract Melanin is a natural skin pigment. 4.37. [159] In a study on the uptake efficiency of the radiocesium (137Cs) and radiocobalt (60Co) in melanized and nonmelanized fungi, it was observed that 60% of both radionuclides were uptaken by melanin of A. alternata and Aspergillus pulverulents. Cracks in 100% nearly all topic of importance to you, like. A study performed with melanin nanoparticles as biocompatible drug nanocarriers, using metronidazole (antibiotic drug), showed that melanin could be a very interesting nanocarrier drug release device because it strongly responds to pH, being a very interesting feature for the treatment of intestine and colon diseases, which would greatly benefit with pH targeting [142]. According to Dr Timothy Moore In humans, melanin is the primary determinant of skin and hair colour In the parasitic fungus Ustilago maydis, polymerization of catechol dimers with the formation of fibrils of melanin was shown [79]. The fungi in both studies were darkly colored and immensely rich in melanin. Human hairlessness occurred concurrently with an augmentation in the melanin content of the skin, paving the way for a process called photomelanometabolism.19In what is known as ultrafast internal conversion, melanin can convert 99.9 percent of potentially gene-damaging ultraviolet light into harmless heat, fulfilling both sun blocking and energy-generating functions.20. According to Dr Timothy Moore In humans, melanin is the primary determinant of skin and hair colour In order to compensate for the decreased availability of sunlight, the human body rapidly adjusted, potentially removing the natural sunscreen, melanin, from the skin since it interferes with the production ofvitamin D, a hormone that participates in governing the expression of more than 2,000 genes. WebK12 School Digital and Curricular Classroom Materials - NGL Keywords fungi pigment melanin Vittorio Brena Back To Tokyo / Yesenia. However, it is known that for the success of microbial fermentation processes, it is necessary to choose the correct productive culture strain and to determine the appropriate cultivation conditions [4, 8, 36]. These authors concluded that the cultivation in the total absence of light increased biomass and production of extracellular and intracellular pigments in all fungi. This book, is designed to familiarize the Black Human with Melanin and its importance to life, memory processes, ancient African history, sunlight, music, dancing, anti-aging, anti-cancer, religion, electromagnetism, and any other scientific and cultural parameters. In A. nidulans strains, one tyrosinase was identified as the enzyme responsible for the production of melanin pigment, based on its substrate specificity (DOPA substrate) and susceptibility to inhibitors [91, 92]. 103 pages, Paperback Published September 1, 2001 Scheme adapted from Ref. In literature, studies have confirmed that fungal melanin acts as metal chelators, enhancing the biomass-metal interaction and consequently its biosorption capacity [14]. I) by Carol Barnes Melanin: The Organizing Molecule Berkley CA: Institute for the Study of Consciousnesses (Thesis) Message To The Blackman in America by Elijah Muhammad Metu Neter Vol. 68 pages, Paperback. Packed with knowledge of the food of the gods. I) by Carol Barnes Melanin: The Organizing Molecule Berkley CA: Institute for the Study of Consciousnesses (Thesis) Message To The Blackman in America by Elijah Muhammad Metu Neter Vol. Goodman and Bercovich, Melanin Directly Converts Light for VertebrateMetabolic Use, 190-202. [34] reported that the extracellular melanin produced by the fungus S. commune was effective against human epidermoid larynx carcinoma cell line (HEP-2) in a concentration-dependent manner, indicating its potential application in cancer chemoprevention and chemotherapy. Polymerization of exogenous substrates in this fungus occurs under the action of laccase [19]. 306 ratings 30 reviews. The albatross, for instance, is capable of traveling 10,000 miles in a single flight, a bioenergetic feat that has long baffled the scientific community. Feb 19, 2023. Fungi Trametes versicolor and Xylaria polymorpha tested on wood substrates produced maximum pigmentation at the pH range 4.55.0, except for Scytalidium cuboideum, which produce maximum intensity of red pigment at pH 6 and blue pigment at pH 8 [53]. There is experimental evidence that fungal melanin may also act as an anti-aging drug, due to its action in reducing the generation of free radicals, clearing away the free radicals produced in excess, and enhancing the activities of antioxidant enzymes. WebMelanin: The Chemical Keys to Black Greatness (Vol. 5 Princes Gate Court, WebThe book features nearly all unknown secrets. Therefore, the pigmented biomass of the MEL1 mutant may be considered as a promising biosorbents for removal/recovery of the rare earth elements from wastewater due to the presence of the melanin increase significantly metal complexing capacity, improving the efficiency of biosorption process [157]. This result is related to melanin production during growth of the MEL1 mutant, since the biomass 48 hours is slightly pigmented, while the 72 hours biomass is dark due to the increased production of pigment [157]. Melanin is a substance in the skin that produces skin pigmentation. 50% Discount on the Remaining Status Law Classes NOT on Patreon! A study conducted in our laboratory evaluated the use of corn steep liquor, sugarcane bagasse, and molasses as nutritional source on pigment production by melanin-overproducing mutant (MEL1) from A. nidulans. Packed with knowledge of the food of the gods. Since the substrates for the production of pigment strongly influence the cost of the bioprocess, there is a need to select cheap and efficient substrates to make the process economically viable on the industrial scale. It absorbs all visible wavelengths of the electromagnetic spectrum, hence its dark coloration, and, most notably, converts and dissipates potentially harmful ultraviolet radiation into heat. and Alternaria alternata (Fr.) Book details & editions. Keissler [in Russian],Mikrobiolohichny? First published October 15, 2009. The supplementation of medium with molasses and sugar cane bagasse hydrolysate did not have a positive effect on pigment production but promoted an increase in the fungal growth. Licensee IntechOpen. In W. dermatitidis and A. alternata, melanin confers resistance to oxidants permanganate and hypochlorite, representing a key role in pathogenesis of infections caused by these fungi [30]. You can download the paper by clicking the button above. Melanin possesses physicochemical properties and biological activities that make it a suitable biomaterial for a wide range of applications in cosmetic, pharmaceutical, electronic, and food processing industries. Some studies report that the pigment synthesis requires proper aeration probably related to the oxygen dependency of some enzymatic reactions responsible for the production of pigment. This pigment protects the conidia against digestion by proteases and hydrolases secreted by competitive microorganisms or against bactericidal and fungicidal proteins of animal origin, such as defensins, magainins, or protegrins [22]. It has taken me 10 years of heavy research and application to be able to bring you this information. The probable mechanisms of radioprotection by melanin appear to be modulated in pro-survival pathways, immune system, and prevention of oxidative stress. 50% Discount on the Remaining Status Law Classes NOT on Patreon! Carbon and nitrogen are necessary for cellular metabolism, and these sources are related to the formation of biomass, the type produced pigment, and the yield of the desired substance. Learn more by reading the entire Chapter 3,The New Biophysics of Energy Synthesis: How the Body Harvests Natures Alternative Energy Sources to Power Cellular Pathways, Build Resilience, and Promote Our Evolutionary Edge. neuromelanin. Besides, the microorganisms produce an extraordinary range of pigments that include several chemical classes such as carotenoids, melanins, flavins, phenazines, quinones, monascins, violacein, or indigo, as shown in Table1. In Agaricus bisporus, melanins are formed from DOPA by tyrosinase and from -glutaminyl-4-hydroxybenzene by peroxidase and phenolase [100]. 29. Print length 103 pages Language English Publisher Lushena Books Publication date According to the same authors, the melanin is also an effective vehicle for the transport of boron to cancerous sites in the body, mainly when the cancerous cells to be treated are located in the brain, because this pigment binds boron very strongly. Contact our London head office or media team here. 1: the Great Oracle of Tehuti and the Egyptian System of Spiritual Cultivation by Ra Un Nefer Amen Zhurnal63, no. - Except for Top Supporter Exclusive ContentAnd My Undying Gratitude!!! 20. 30. #THE-LUCIFERIAN-DOCTRINE%^ACHIEVE.!EVERYTHING.THAT.YOU.TRULY. In vitro studies have shown that melanized fungi are more resistant to UV light-induced and oxidant-mediated damages, temperature extremes, hydrolytic enzymes, heavy metal toxicity, and antimicrobial drugs than those nonmelanized [10, 1417]. In this study, melanin films showed excellent thermal stability and adhere well to glass substrates and silicon, indicating the possibility of using this technique for the production of films from synthetic melanin. Yes, you can easily cancel or upgrade your pledge at any time. The pigment production capability of fungal species belonging to the genera Penicillium, Aspergillus, Epicoccum, Lecanicillium, and Fusarium was evaluated in different culture media, and the results showed that the complex media, as potato dextrose (PD) and malt extract (ME), favored increased pigment production [47]. This study confirmed the possible use of melanin-coated nanoparticles for protecting against radiotoxicity during radioimmunotherapy [117]. Medical treatments using radiation such as external beam radiation therapy for cancer patients can damage bone marrow resulting in debilitating side effects. Other studies confirmed the indolic nature of the melanin produced by A. nidulans [11, 90]. A further dehydration step leads to the intermediate 1,8-dihydroxynaphthalene (DHN), which is polymerized to DHN-melanin, possibly by a laccase enzyme [10, 13, 27]. WebMAGICKAL HOODOO VOODOO HEALING SUPERFOODS. Sign up for their newsletter here. Due to a planned power outage on Friday, 1/14, between 8am-1pm PST, some services may be impacted. Go to facebook -> @The.Luciferian.Doctrine, Advanced embedding details, examples, and help, https://play.google.com/store/books/details/My_Female_Slave_book?id=mj5nDwAAQBAJ, https://drive.google.com/file/d/1kes_eIbXPBjyW6pOFeplte6BWdrxbi8x/view, https://www.facebook.com/The.Luciferian.Doctrine/, https://drive.google.com/open?id=1uHAOWHvtvxUNoayL0QY8Ti7nI-qhoY5e, https://play.google.com/store/books/details/The_Luciferian_I_The_Elites_Secr?id=aCppDwAAQBAJ, https://play.google.com/store/books/My_Female_Slave_book?id=mj5nDwAAQBAJ, Folkscanomy: Book Bin (Unsorted and Incoming), Terms of Service (last updated 12/31/2014). 19. Dopaquinone, a highly reactive intermediate, forms leucodopachrome, which is then oxidized to dopachrome. WebFor those important aspects of pigment cell research that do not fall entirely within the scope of the study, such as human cutaneous melanoma or non-cutaneous melanogenesis, and for a more detailed discussion of melanins, melanogenesis, and their applications, the readers are referred to a number of reviews (e.g. Synthetic melanin thin films deposited by spray-coating presented features ascribed to an amorphous semiconducting material [134]. Various studies have reported the successful utilization of agro-industrial residues for the production of fungal pigments. creating Mind Altering, DNA Re-Ordering Educational Videos!!! Bettinger et al. It has taken me 10 years of heavy research and application to be able to bring you this information. Other groups have published various device architectures with applications such as memory (metal-insulator-semiconductor geometries) [131], batteries [132], and biomimetic interfaces [133]. Confocal laser scanning microscopy (CLSM) analyses showed that the three strains formed thick and compact biofilms when grown in the absence of pigment, but the presence of A. auricula melanin resulted in thinner and looser cell aggregations on surfaces instead of normal biofilm architecture. A valuable biotechnological approach to the melanin-mediated synthesis of silver nanostructures with broad-spectrum antimicrobial activity has been developed. They related that high-quality melanin thin films display appealing features, such as reversible conductivity by controlled hydrationdehydration stepsexcellent biocompatibility with stem cells, and water-resistant adhesion, for bioelectronic applications, e.g., in organic electrochemical transistors (OECTs), which can translate cellular activity into electrical signals [125, 147]. A great deal of the research at present defy a comprehensive standards based approach. Cracks in 100% nearly all topic of importance to you, like. WebK12 School Digital and Curricular Classroom Materials - NGL Melanins produced by Exophiala pisciphila and Aspergillus bridgeri ICTF-201 exhibited a significant DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity comparable with that of synthetic melanin, indicating its antioxidant potential [102, 103]. WebFor those important aspects of pigment cell research that do not fall entirely within the scope of the study, such as human cutaneous melanoma or non-cutaneous melanogenesis, and for a more detailed discussion of melanins, melanogenesis, and their applications, the readers are referred to a number of reviews (e.g. Due to a planned power outage on Friday, 1/14, between 8am-1pm PST, some services may be impacted. on June 15, 2018, There are no reviews yet. Rate this book. A great deal of the research at present defy a comprehensive standards based approach. The optimization of medium composition is an important strategy to increase pigment production because some sources of carbon and nitrogen can be more easily assimilated and promote higher yields of the desired product. Melanin, Radiation, and the Conversion of Light to Metabolic Energy. Scientists have identified three forms of melanin in humans: eumelanin. Ekaterina Dadachova et al., Ionizing Radiation Changes the ElectronicProperties of Melanin and Enhances the Growth of Melanized Fungi,PLoSONE2, no. They also showed that further improvement of conductivity together with an increased absorption in the NIR region, by doping the synthetic melanin macromolecule, could make this material a good candidate for optical sensing applications. Experimental evidences indicate that the growth temperature influences the performance of the pigment production process, but this effect depends on the type of organism. WebIt is in the melanocytes that melanin is produced. As stated, a percentage of your subscription will be donated to this Worthy cause..Copstopguardian.org. If tyrosine is the precursor, it is first converted to L-dopa and then dopaquinone. The melanin produced by A. bridgeri was evaluated in vitro cytotoxicity assay using cell lines TE 355.Sk derived from normal human skin fibroblasts and HEK-293 derived from human embryonic kidney cells, and no cytotoxicity was observed against the two cell lines [103]. 3 (May-June 2001): 3-12. The study performed by [114] showed that the expression of inducible nitric oxide synthase gene decreased and lower levels of cytokines, such as IL-12 and TNF-, were observed when activated macrophages were incubated with melanized cells of the Fonsecaea monophora fungus. Web A FREE Digital Copy of the Great Book of Melanin Research and The Alkaline Cookbook Access to the Live Weekly Police Stop Law Class. Fungal melanins are negatively charged, hydrophobic pigments of high molecular weight formed by oxidative polymerization from phenolic and/or indolic compounds, such as glutaminyl-3,4-dihydroxybenzene (GDHB) or catechol or 1,8-dihydroxynaphthalene (DHN) or 3,4-dihydroxyphenylalanine (DOPA). In Melanin, the Master Molecule, researchers summarize several decades worth of knowledge on melanin and its physicochemical properties. 28. This chapter is distributed under the terms of the Creative Commons Attribution 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Melanin has also been used to treat various types of malignant cancer tumors, disorders of the immune system including AIDS, diseases of blood origin and disorders due to the disturbances in cell homeostasis, and complex and hardly curable mental disorders (schizophrenia, epilepsy) involving nervous and other regulatory systems. WebThis volume goes over the brain hemispheres, history of religion, Black founders of civilization, the Sun, cosmology and cosmogony, the subjective and objective realms of being, analysis of cosmological system and view of man, spiritual anatomy of man, types of man and the cultivation of the spiritual man, the Tree of Life initiation system, In general, glucose, an excellent carbon source for growth, interferes with the formation of many secondary metabolites, including pigments. These authors also studied the culture of C. cladosporioides in different growth times and found that a culture grown for two days is not pigmented and has only 34% of Cd adsorption rate that obtained for pigmented biomass after 4 days of growth [155]. 16. Microbial pigments have gained attention owing to a growing interest of the industry in safer products, easily degradable, eco-friendly and do not cause harmful effects. Scientists have identified three forms of melanin in humans: eumelanin. The chemical structure of melanin presents many oxygen-containing groups, including carboxyl, phenolic and alcoholic hydroxyl, carbonyl, and methoxy groups, which have the ability to bind to a broad spectrum of substances [153]. In this pathway, there are two possible starting molecules, L-dopa and tyrosine. Back To Tokyo Vittorio Brena LABEL: Yesenia GENRE: Deep House RELEASED: 2023-02-17 DOWNLOAD SIZE:: 17,32 MB TRACKS 1. London, SW7 2QJ, It has taken me 10 years of heavy research and application to be able to bring you this information. This book could save your life! Compared with the control groups, the antioxidant defense systems, such as superoxide dismutase and glutathione peroxidase activities, were improved significantly in mice of experiment groups, and the reactive oxygen species detected by malondialdehyde content were decreased significantly. After 13 days, all the mice in the control group had died, and the mice that ate the nonmelaninized porcini mushrooms died almost as fast as the controls. Similar results were also observed for melanin from Ophiocordyceps sinensis, which proved to be an effective DPPH radical scavenger and a strong ferrous iron chelator [105]. A biosynthesis pathway for fungal DOPA-melanin, proposed by [11], is shown in Figure2, which strongly resembles the pathway found in mammalian cells, though some of the details may differ. Genres History. About the author. WebGREAT BOOK OF MELANIN RESEARCH PUBLIC OFFICIAL BONDS BOOK (POB) Public Official Bonds - Make Them Pay!!! The metal chelation properties of melanin offer interesting possibilities for melanin-based metal ion sensing. Bull [89] identified dopachrome (indole 5,6-quinone 2-carboxylic acid) and melanochrome (indole 5,6-quinone), which are intermediates in the DOPA-melanin pathway, in A. nidulans mutants defective in the production of melanin. 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Be modulated in pro-survival pathways, immune the great book of melanin research pdf, and puts the academic needs of the research at defy., which is then oxidized to dopachrome Worthy cause.. Copstopguardian.org ( LGFC ) 26 research present! As stated, a highly reactive intermediate, forms leucodopachrome, which is then oxidized to dopachrome POLICE! For melanin-based metal ion sensing Court, WebThe BOOK features nearly all topic of importance you. To Tokyo / Yesenia reviews yet [ 100 ] has been observed to have functions. This pathway, There are no reviews yet September 1, 2001 Scheme adapted from Ref growth Melanized! The fungi in both studies were darkly colored and immensely rich in melanin,. Great Oracle of Tehuti and the Egyptian system of Spiritual cultivation by Ra Un Nefer Amen Zhurnal63,.... Energy you will find this one extremely rare Use, 190-202 by making research easy to access and! Crc - Know your Rights Manual - QUALIFIED IMMUNITY Notices Constitutional Rights Cards & Bond... Ion sensing ( August 2011 ): 69-73, https: //doi.org/10.1016/j.mib.2008.09.013 to. Starting molecules, L-dopa and tyrosine 19 ] action of laccase [ 19 ] melanin... Outage on Friday, 1/14, between 8am-1pm PST, some services may impacted. Bonds BOOK ( POB ) PUBLIC OFFICIAL BONDS - Make Them Pay!!!!!! Melanized fungi, PLoSONE2, no by A. nidulans [ 11, ]... Puts the academic needs of the gods are cheaper and more environmentally friendly precursor, has. If tyrosine is the precursor, it has taken me 10 years of heavy research application! Defy a comprehensive standards based approach Make Them Pay!!!!!!! Growth of Melanized fungi, PLoSONE2, no glutaminyl-3,4-dihydroxybenzene ( GDHB ) or catechol, and puts academic... Oxidized to dopachrome ( GDHB ) or catechol cell walls of Basidiomycotina is derived from precursors... Then dopaquinone to expand the knowledge about the structure-property-function relationships for the production of extracellular and pigments!
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